Antithyroid action of tetraethylthiuram disulfide.
نویسندگان
چکیده
Tetraethylthiuram disulfide (Antabuse) has been demonstrated to be clinically useful in treating alcoholism (1). The compound has been shown to inhibit the oxidation of acetaldehyde (2) and, further, to inhibit the action of rat liver xanthine oxidase to the extent of 71 per cent, and the succinoxidase system 100 per cent (3). Examination of the chemical structure of Antabuse indicates that it contains two atomic groupings found in many antithyroid drugs, i.e. -N-C-
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ورودعنوان ژورنال:
- The Journal of biological chemistry
دوره 211 1 شماره
صفحات -
تاریخ انتشار 1954